THE MOBILE INSULIN TITRATION INTERVENTION (MITI) FOR INSULIN GLARGINE TITRATION IN AN URBAN, LOW-INCOME POPULATION: RANDOMIZED CONTROLLED TRIAL PROTOCOL

The Mobile Insulin Titration Intervention (MITI) for Insulin Glargine Titration in an Urban, Low-Income Population: Randomized Controlled Trial Protocol

BackgroundPatients on insulin glargine typically visit a clinician to obtain advice on how to adjust their insulin dose.These multiple clinic visits can be costly and time-consuming, particularly for low-income patients.It may be feasible to achieve insulin titration through text messages and phone calls with patients instead of face-to-face clinic

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Increased zinc and manganese in parallel with neurodegeneration, synaptic protein changes and activation of Akt/GSK3 signaling in ovine CLN6 neuronal ceroid lipofuscinosis.

Mutations in the CLN6 gene cause a variant late infantile form of neuronal ceroid lipofuscinosis (NCL; Batten disease).CLN6 loss leads to disease clinically characterized by vision impairment, motor and cognitive john tory hair dysfunction, and seizures.Accumulating evidence suggests that alterations in metal homeostasis and cellular signaling path

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